In the tumor model BoC32, we observed in SR tumors an upregulation of IL-6 family members such as Ciliary Neurotrophic Factor Receptor (CNTFR) and Interleukin 6 receptor (IL6R) (Additional file 7: Table S6), known to be able to signal via Janus kinase (JAK)/(STAT) [78]. Here, IL6R is linked to neoplasm.