The context-specific pathway of NETs induction provides attractive target for interference of NETs formation under different malignancy, as exemplified by blocking IL-8 [43], Cathepsin C (CTSC) [46], Amyloid β [47] or CXCR-1, -2 [45], which are either tumor-derived pro-inflammatory factors or the receptors on neutrophils responsible for NETosis upon activation. This evidence concerns the gene CTSC and neoplasm.