CCDC25 and cancer: Moreover, the accumulation of NETs in distant organs may serve as a directional chemotaxis factor for the recruitment of CTCs, as observed in a recent study where NETs DNA abundant in liver metastasis of breast cancer and colon cancer patients, acts as a chemotactic factor to attract CTCs through coiled-coil domain containing protein 25 (CCDC25), a transmembrane protein present on cancer cells [25], providing a possible mechanism to explain the site preference of metastasis and a therapeutic target in inhibiting metastasis .