In mouse models of experimental cerebral malaria (ECM), phagocytosis of parasite-derived vesicles by astrocytes and IEs by brain macrophages (microglia cells) led to increased production of inflammatory mediators such as CXCL-10 and high levels of CXCL-10 predicted mortality in ECM [66, 67]. Here, CXCL10 is linked to cerebral malaria.