At 25 mg/kg i.p., ODSH did not significantly decrease airway HMGB1 levels in PA-infected CF mice, compared to mice treated with vehicle, but did reduce the levels of airway HMGB1 to 0.72 ± 0.14 AU, which was not significantly different from those in PA-infected WT control mice (0.36 ± 0.09 AU) (Fig. 5B). This evidence concerns the gene HMGB1 and cystic fibrosis.