Here, we determine that in Huh7-GCGR hepatoma cells, the upregulation of RAMP2 also acutely increases efficacy for cAMP production in response to GCG stimulation (Figure 3A; Table 1); this is consistent with our previous finding that a reduction of RAMP2 in Huh7 cells is associated with a decrease in cAMP production with GCG [19]. This evidence concerns the gene GCG and hepatocellular carcinoma.