STAT4 and cancer: Favorable response to cancer immunotherapy was found to be associated with the increase in cell cycle, DNA repair, and regulation of chromosome organization and the decrease in innate immune response, cytokine production, myeloid leukocyte activation, interleukin‐12 (IL‐12)/signal transducer and activator of transcription 4 (STAT4) pathway, and NFAT pathway in rectal mucosa.