Fig 8 panels f-j show drastic alterations in the morphology of islets after destruction of β-cells, leaving α-cells clustered together. The complete or near-complete destruction of β-cells reflect the full-blown diabetes in rats injected with streptozotocin. The extent by which the remaining β-cells release insulin is unknown, but considered negligible based on the absence of β-cells in the diabetic rats shown in Fig 8. This evidence concerns the gene INS and diabetes mellitus.