CD4 and tuberculosis: Similarly, a prospective cohort of 1862 ART-naïve immunosuppressed (CD4 counts < 200 cells/mm3) individuals in South Africa reported that those with an MLR < 5th or > 95th percentile had a higher hazard (aHR 2.47; 95% CI, 1.39, 4.40) for development of TB during the first 5 years of ART [8].