GSTM1 and hemolysis: Hemolytic anemia is characterized by low Hb levels accompanied by jaundice, reticulocytosis, increased plasma LDH and indirect bilirubin levels, decreased plasma haptoglobin levels, and elevated urobilinogen in urine.13 It is distinguished as AIHA and NIHA; AIHA refers to RBC destruction by antibodies directed against erythrocyte antigens and is diagnosed by a positive Coombs test.14 In contrast, NIHA refers to RBC destruction in the absence of antibodies and is characterized by clinical signs of hemolysis and a negative Coombs test.7