SAMD9 and familial tumoral calcinosis: The defect in NFTC is related to SAMD9, a tumor suppressor and anti-inflammatory protein.1 Normophosphatemic familial tumoral calcinosis (NFTC) is less prevalent than HFTC and typically presents in the first year of life as a non-specific erythematous rash and mucosal inflammation.1 Hyperphosphatemic familial tumoral calcinosis (HFTC) has been demonstrated to result from a genetic mutation in one of the three phosphate-regulatory genes FGF23, KL, and GALNT3 (MIM #617993, #617994, #211900), though most commonly identified in the last-mentioned.