Additionally, it well known that cancer cachexia induces the chronic activation of AMPK in skeletal muscle; however, regular exercise can prevent the chronic induction of muscle AMPK in tumor‐bearing mice (Puppa et al., 2012), further underscoring exercise's effect in preventing indices of cachexia (Coletti et al., 2016; Mehl et al., 2005; Pigna et al., 2016; Vanderveen et al., 2020; Jee et al., 2016). Here, PRKAA2 is linked to cancer.