NFKB1 and neoplasm: Constitutive NF-κB activity in cancer cells can also promote tumour development in a cell-autonomous manner by promoting cell proliferation and preventing apoptosis by inducing the expression of anti-apoptotic genes such as the caspase inhibitor FLIP, the inhibitor of apoptosis proteins cIAP1/2 and XIAP, as well as pro-survival members of the BCL2 protein family [14].