ACE2 and obesity due to melanocortin 4 receptor deficiency: In the context of SARS‐CoV‐2 infection, it has also been proposed that hyperglycemia potentially changes the glycosylation of ACE2 and the viral spike protein S, altering binding of S to ACE2 and the degree of the immune response to the virus,64 thereby contributing to increased susceptibility of patients with MetS and type 2 diabetes (both strongly associated with obesity) to get infected with SARS‐CoV‐2 (Figure 1).