FAF1 and cancer: Should mammalian FAF1 play an analogous role during CMG helicase disassembly to C. elegans UBXN‐3, it would then be interesting to explore whether partial inactivation of TIMELESS‐TIPIN, for example via Proteolysis Targeting Chimeras or PROTACs (Maniaci & Ciulli, 2019; Verma et al, 2020), might induce synthetic lethality in cancer cells that lose the FAF1 gene during their development.