Should mammalian FAF1 play an analogous role during CMG helicase disassembly to C. elegans UBXN‐3, it would then be interesting to explore whether partial inactivation of TIMELESS‐TIPIN, for example via Proteolysis Targeting Chimeras or PROTACs (Maniaci & Ciulli, 2019; Verma et al, 2020), might induce synthetic lethality in cancer cells that lose the FAF1 gene during their development. The gene discussed is CASK; the disease is cancer.