Compared with public data sets of conventional gastric adenocarcinoma (TCGA, Firehose Legacy), the frequency of GNAS mutation was significantly higher in GEN-FGML (7/34, 20.6% vs. 21/395, 5.3%, p < 0.01) whereas the frequency of TP53 mutation was significantly lower in GEN-FGML (0/34, 0% vs. 190/395, 48.1%, p < 0.01). Here, TP53 is linked to gastric adenocarcinoma.