In addition, analysis of PD-L1 expression in a panel of melanoma cell lines confirmed the hypoxic induction of Pd-l1 mRNA expression in murine B16 cells [15, 17], but also revealed that hypoxia differentially regulates (IFNγ-induced) PD-L1 expression in a panel of human melanoma cell lines (Figs. 2A, 4B). Here, CD274 is linked to melanoma.