In addition, inhibition of aggrecan cleavage to prevent tissue degradation may be desired in one tissue, such as the articular cartilage but simultaneously may have adverse effects in other tissues, such as tendon, where aggrecan accumulation resulted in decreased mechanical properties, or the aorta, where aggrecan and versican accumulated in thoracic aortic aneurysms potentially promoting aortic dissection and rupture (Velasco et al., 2011; Wang et al., 2012; Cikach et al., 2018). The gene discussed is ACAN; the disease is dissection.