On the other hand, The expression of DNMT3a is low in normal colonic epithelial cells FHC and primary normal colon epithelial cells 1, 2, and 3, and relatively higher in colon cancer cells (HT-29, HCT 116, HCT-15, SW48, SW480, RKO, and LoVo). This evidence concerns the gene DNMT3A and malignant colon neoplasm.