High-throughput sequencing data across RCC tumors have identified several pivotal epigenetic drivers with a high mutated frequency, including VHL, SETD2, BAP1, and PBRM1 (Sato et al., 2013; Dizman et al., 2020; Wang X. M. et al., 2020). Here, PBRM1 is linked to renal cell carcinoma.