MKI67 and neoplasm: Moreover, we also conducted the tumor xenograft studies to assess the oncogenic roles of KAT2A in vivo. We observed that KAT2A depletion significantly impeded the tumor growth relative to those in the control groups, which was compared by tumor weight, tumor volumes, and intratumor Ki-67 IHC staining scores (Figures 2E,F and Supplementary Figure 2B).