Lastly, we further conducted the Caki-2-derived orthotopic ccRCC model in vivo and found that AZD3965 was notably effective in ccRCC tumors with overexpressed KAT2A to improve the overall prognosis of mice, which was quantified by serial bioluminescence signals and Kaplan-Meier analysis (Figure 6K). This evidence concerns the gene KAT2A and nonpapillary renal cell carcinoma.