In keeping with existing mouse models (Fukada et al., 2012), we find that inactivation of hdac6 or sirt2 does not cause a visible external phenotype in D. rerio. No overt phenotypes characteristic of cilia dysfunction, such as body curvature, hydrocephalus, kidney cysts or retinal degeneration were observed in homozygous mutants or their progeny, ruling out maternal contribution as a modifying factor (Sullivan-Brown et al., 2008; Shi et al., 2017; Maerz et al., 2019). This evidence concerns the gene HDAC6 and Hydrocephalus.