KRAS and neoplasm: For example, DEPDC1 has been shown to activate NF-κB and E2F signaling pathways to accelerate cell cycle progression, and to promote the K-RAS and Wnt/β-catenin signaling pathways to drive tumor cell proliferation and metastasis (Feng et al., 2017; Huang et al., 2017; Qu et al., 2018).