In recent years, several reports have also shown that DEPDC1 is aberrantly upregulated in various tumors and is involved in the occurrence and development of HCC (Amisaki et al., 2019; Guo et al., 2019), breast cancer (Zhao et al., 2019), lung cancer, colorectal cancer (Wang et al., 2020), and glioblastoma (Kikuchi et al., 2017). Here, DEPDC1 is linked to hepatocellular carcinoma.