DEPDC1, DEP (disheveled, EGL-10, pleckstrin) domain-containing 1 protein, is a novel oncoantigen upregulated in multiple types of cancers, including HCC (Kanehira et al., 2007; Qu et al., 2018; Zhao et al., 2019; Zhu et al., 2020). The gene discussed is DEPDC1; the disease is cancer.