Rather, a naturally-spliced mutant TCF11ΔN resembles Nrf2 with largely consistent structure and function in regulating similar sets of target genes. Interestingly, the tumor-preventing effect of Nrf1α/TCF11 seems to be accompanied by certain constitutive activation or repression of critical genes for improving the overall survival rates of patients with hepatoma. The gene discussed is NFE2L2; the disease is neoplasm.