Rather, a naturally-spliced mutant TCF11ΔN resembles Nrf2 with largely consistent structure and function in regulating similar sets of target genes. Interestingly, the tumor-preventing effect of Nrf1α/TCF11 seems to be accompanied by certain constitutive activation or repression of critical genes for improving the overall survival rates of patients with hepatoma. This evidence concerns the gene NFE2L1 and neoplasm.