Upon lack of such amino acid re-editing by peptide: N-glycosidase (PNG1), this causes an evident decrease in the rheostat capacity of Nrf1α/TCF11, and even loss of PNG1 or its mutations results in inactivation of Nrf1α/TCF11, manifesting inflammation and adrenal insufficiency (66–68). Here, NGLY1 is linked to Adrenal insufficiency.