In fact, accumulating evidence reveals that Nrf1 exerts an important role in embryonic development (6, 7), osteoblastogenesis (8, 9), life quality control of proteostasis by proteasome (10, 11) and metabolism (12–14), anti-inflammatory immune response (15), and anti-tumor cytoprotection against hepatoma (16, 17), in addition to redox stress defense (18, 19). Here, NRF1 is linked to hepatocellular carcinoma.