More excitingly, restoration of Nrf1α is allowed for significant mitigation of Nrf1α−/−-exacerbated tumor to similar wild-type extents, while its malignant growth is further suppressed or even abolished by TCF11 restoration, with complete coagulative necrosis of tumor tissues (Figures 7B and S8). The gene discussed is NFE2L1; the disease is neoplasm.