Taken altogether, it is demonstrated that Nrf1α and TCF11, but not Nrf2, are conferred for an intrinsic capability to regulate those genes critical for improving the survival rate of patients with HCC, such that Nrf1α or TCF11 perform a strikingly disparate effect from that of Nrf2 on human hepatoma (Figure 9D). The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.