This is further supported by pathohistological results of the hematoxylin and eosin (HE) staining, revealing that malignant progression of Nrf1α−/− -derived tumor xenografts was substantially suppressed by restoration of either Nrf1α or TCF11 with complete coagulative necrosis of tumor tissues (Figure S8). This evidence concerns the gene NFE2L1 and neoplasm.