Along the same lines, other studies have linked increase of cytokines, like CXCL9, CXCL10, CXCL11, and CXCL19, under ICIs as a sign of enhanced general immune reactivity with both subsequent tumor responses and development of irAE in NSCLC (30–32). This evidence concerns the gene CXCL10 and non-small cell lung carcinoma.