Recently, TAMs play a distinctly supportive function to promote GC cells’ invasion, in which TAMs transfer tumor-derived extracellular vesicles containing RNA and proteins (TGF-β, activated Src, Wnt3, and HIF1α) to peritoneal stromal cells and elicit a pro-tumor microenvironment, such as induction of MMT of PMCs (42). This evidence concerns the gene HIF1A and neoplasm.