The dual-luciferase reporter gene system results indicated that miR-338-5p overexpression decreased the luciferase activity in NPC cells co-transfected with wild-type WNT2B (wt-WNT2B), instead of the mutant WNT2B (Mut-WNT2B), while silencing of miR-338-5p had opposite effects (P < 0.05, Figures 4B, C). This evidence concerns the gene WNT2B and nasopharyngeal carcinoma.