Nevertheless, PI3K likely operates downstream or in parallel to the HH pathway in BCC, similar to our results for MTOR in Ptch1fl/fl; Gli1-CreERT2 BCCs (48) and consistent with models where MTOR acts downstream of the HH pathway in Ptch1+/−/SKH-1 BCCs (60). Here, PTCH1 is linked to skin basal cell carcinoma.