In addition, Ki67 and Tunel staining results revealed that Ki67 levels in tumor cells of mice dropped significantly and the number of cells in the early stage of apoptosis increased markedly after treatment with O-MSNs (Figure 8, P<0.05), but the decline in Ki67 levels in mice cells was even more dramatic and the number of cells in the early stage of apoptosis was much more prominent after treatment with OH-MSNs (Figure 8, P<0.05). Here, MKI67 is linked to neoplasm.