EGR1 and ovarian cancer: In our study, it was also observed that the expression of EGR1 in HGSOC patients with platinum resistance was significantly downregulated and was positively correlated with the expression of MGRN1. Although the mechanism by which MGRN1 regulates EGR1 is still unclear, a strong association between MGRN1 mRNA expression and EGR1 mRNA expression was noted in the TCGA ovarian cancer dataset (Additional File 1 and Figure S1).