Third, some investigators found that the ACEI/ARB combination could alleviate glomerular and tubulointerstitial injury because of the resulting reduction in the L-FABP and ET-1 levels, which are correlated with tubulointerstitial lesions and renal fibrosis (Kamijo et al., 2005; Nakamura et al., 2007). The gene discussed is EDN1; the disease is renal fibrosis.