The immunopathogenesis of BD has been widely studied and several immune system cells and cytokines may be involved, primarily those that are proinflammatory, accelerating impairment of endothelial function.7 One study reported that many of these inflammatory cytokines were found at elevated levels in serum from BD patients and, because of this evidence, TNF-α and IFN-α antagonists demonstrated good efficacy and have been adopted as agents for treatment of BD.7 Here, TNF is linked to Behcet disease.