L1CAM-specific CAR T cells more easily killed tumor cells in 2D cocultures (SS-BB/ζ L1CAM-CAR T cells lysed: 95.9 ± 0.8% in 2D, 39.9 ± 27.1% in 3D; LS-BB/ζ L1CAM-CAR T cells lysed: 92.1 ± 3.6% in 2D and 42.4 ± 22.0% in 3D; Figure 5E). This evidence concerns the gene L1CAM and neoplasm.