STAT3 and colitis: found that Enterotoxigenic Bacteroides fragilis (ETBF) promotes colon tumorigenesis by stimulating immune response via Th17 cells in mouse CRC model, ETBF stimulates rapid colitis and colon tumors in multiple intestinal neoplasia (Min) mice and induce activation of transcription-3 (Stat3) in the colon of Min mice, Stat3 signaling is necessary for the generation of TH17 cells, and IL-17 produced by CD4+ Th17 is sufficient to induce tumorigenesis in the absence of γδ T cells (43).