This might be similar to our previous observations showing that variants of apoL-I gene are associated with TG, apoC-III, and apoE levels in nonobese Chinese, but not in overweight/obese subjects because in obesity, the genotype effects on lipid levels might be masked by obesity-associated metabolic abnormalities (39). This evidence concerns the gene APOC3 and obesity due to melanocortin 4 receptor deficiency.