CYP11B2 and adrenal cortex adenoma: CYP11B2 IHC has revealed diversities in the histopathology of adrenals from patients with PA, including APA (CYP11B2-expressing adrenocortical adenoma) and adrenals with small CYP11B2-expressing cell nests, called aldosterone-producing cell clusters (APCCs) (45) or aldosterone-producing micronodules (APMs) (47).