An increased occurrence of homozygosity for C allele and wild-type G allele for IL-6-174 (a promoter of reduced plasma levels of IL-6, an inflammatory mediator) has also been reported in fatigued breast cancer survivors while others reported significant cytokine association with CrF among women with breast cancer GG genotypes for TNFα-308 (38, 39). The gene discussed is IL6; the disease is breast cancer.