Various important pathways involved in PAH, including Complement and coagulation cascades (rno04610), Circadian rhythm (rno04710), Renin-angiotensin system (rno04614), Systemic lupus erythematosus (rno05322), and B cell receptor signaling pathway (rno04662), were significantly enriched in the dysregulated mRNAs (Figure 2D). The gene discussed is REN; the disease is pulmonary arterial hypertension.