KCNK3 and pulmonary arterial hypertension: Downregulation, inhibition or inactivating mutations of TASK-1 channels have been shown to contribute to detrimental vascular remodeling in the PAH disease phenotype (Ma et al., 2013; Boucherat et al., 2015; Antigny et al., 2016; Navas et al., 2017; Cunningham et al., 2019), while pharmacological interventions that enhances TASK-1 channel current have been found to be beneficial in PAH treatment (Olschewski et al., 2006; Ma et al., 2013; Antigny et al., 2016; Cunningham et al., 2019).