A prospective observational cohort study revealed that autoimmunity in severe COVID-19 patients is mediated through binding of immunoglobulin A (IgA) antibodies to human surfactant protein B (SP-B) and surfactant protein C (SP-C) leading to reduced levels of pulmonary surfactant (Sinnberg et al., 2021). This evidence concerns the gene SFTPB and COVID-19.