Emerging evidence suggests that cardiac GLUT5 expression is upregulated in disease states, demonstrated by increased GLUT5 mRNA expression in type 2 diabetic Zucker diabetic fatty rat cardiac tissue (Daniels et al., 2021), and in left-ventricular biopsies from aortic stenosis and hypertrophic cardiomyopathy patients (Mirtschink et al., 2015). This evidence concerns the gene SLC2A5 and aortic stenosis.