More recently, senescent astrocyte accumulation was shown to promote the formation of hyperphosphorylated tau aggregates, and the reduction of the senescent astrocytes prevents PS19 tau transgenic mice from cognitive decline, as well as a decline in tau pathology has been reported (Bussian et al., 2018), which shows a close interplay between the tau pathology and reactive astrogliosis. The gene discussed is MAPT; the disease is Mental deterioration.