MAPT and Alzheimer disease: We, assessed the hippocampal and cortical tau expression as well as the tau phosphorylation levels using antibodies raised against N- and C-terminus of tau proteins, and specific phospho-sites are known to be hyperphosphorylated in AD (Augustinack et al., 2002; for a review, see Sergeant et al., 2008) as well as pathological epitopes which are only detected when neurofibrillary processes are present (T212/S214 and S422) (antibody epitopes are represented on Figure 2A).