CD274 and neoplasm: Using the Ventana SP142 immunohistochemistry assay (Ventana Medical Systems), baseline of PD-L1 expression on ICs was evaluated with 4 scoring bins IC3 (≥10%), IC2 (5–10%), IC1 (≥1%,) and IC0 (<1%). The PD-L1 expression on tumor cells (TCs) was assessed as less than 1% (TC0) or at least 1% (TC1/2/3)