This finding is unsurprising, as ApoE ε4 status conveys greater risk of neurocognitive and cardiovascular disease for females (Mortensen and Høgh, 2001; Riedel et al., 2016), and sex has been found to moderate associations between amyloid burden, ε4 status and functional connectivity in the DMN (Damoiseaux et al., 2012; Caldwell et al., 2019). This evidence concerns the gene APOE and cardiovascular disorder.