Despite that an increase in IFNγ producing E7-specifc CD8+ T cells was observed in spleen samples taken from the mouse being cured with the combinative form of anti-OX40/vaccine and PD-1 blockade, both in periphery and the tumor, these cells became apoptotic (Shrimali et al., 2017[87]). The gene discussed is CD8A; the disease is neoplasm.