CD274 and hepatocellular carcinoma: Morales-Kastresana et al. explained that triple combination approach consisting of anti-OX40 and Immunostimulatory monoclonal Antibodies (ISmAb) anti-CD137 and anti-B7-H1 (PD-L1) promoted survival rate among mice that carried hepatocellular carcinomas in a CD8-dependent fashion and were synergized with adoptive T-cell therapeutic strategy that utilized activated OVA-specific TCR transgenic OT-1 and OT-2 lymphocytes.