Ju et al. reported trivial effects on established RCC and Renca tumors, when utilizing monotherapy with anti-4-1BB mAb or the cytotoxic drug or 5-fluorouracil (5-FU), however, as they demonstrated, with the combinative form of anti-4-1BB mAb and 5-FU eliminated the tumors in more than 70 % of mice. Here, TNFRSF9 is linked to renal cell carcinoma.