HMGB1 and neoplasm: The senescence-associated markers that are usually used to identify SASP in tumor tissue samples include p16, p15, p53, ADP-ribosylation factor (ARF), p21, differentially expressed in chondrocytes protein 1 (DEC1), decoy receptor 2 (DCR2), and high mobility group box 1 (HMGB1) [8–12].