Waugh and Wilson [43] reported IL-8 secreted by tumor cells plays an important role in the tumor microenvironment and observed that the expressions of the IL-8 receptors, CXCR1 and CXCR2, were elevated in cancer cells, endothelial cells, and tumor-infiltrating neutrophils and macrophages. Here, CXCL8 is linked to neoplasm.