Notably, when this human sample data was used to test the hypothesis that gene expression could be predictive in disease detection using a receiver operating characteristic (ROC) curve analysis, we observed that while MMP9 expression was moderately diagnostic (AUC=0.683), the combination of MMP9 with CAIX could strongly distinguish tumor samples from controls (AUC=0.946) (Fig. 1e). The gene discussed is CA9; the disease is neoplasm.