VEGFA and age-related macular degeneration: For example, bevacizumab, the neutralizing monoclonal antibody (mAb) against vascular endothelial growth factor A (VEGFA), has been approved for treating seven different advanced human cancers (with or without chemotherapy) and is widely used off-label in the treatment of various ocular diseases such as age-related macular degeneration as a common alternative to the approved anti-VEGFA antibody ranibizumab2,4.