Large-scale sequencing studies of GC identified and confirmed frequent gene amplifications in genes encoding receptor tyrosine kinases (e.g., ERBB2, ERBB3, EGFR, FGFR2, MET, and VEGFR) and somatic mutations in p53, ARID1A, PIK3CA, SMAD4, CDH1 (E-Cadherin), and RHOA genes, with high frequencies in the last two specifically among diffuse-type GC (DGC) [7–12]. Here, CDH1 is linked to gastric cancer.