GHRH and childhood malignant neoplasm: Moreover, retesting has been performed with the use of GHRH + arginine in the vast majority of patients (n = 54): this combined test represents one of the most powerful GH stimulation tests showing less intra-individual variability, but remains questionable in several patients, especially in the presence of primary hypothalamic dysfunction, as in childhood cancer survivors or NSD, as abovementioned50.