Previously, a case–control study by Kanda et al. from Japan with 160 cases and 1,600 controls showed that the highest pancreatic cancer risk was observed among ever drinkers who carry the ADH1B*2/*2(fast activity) in combination with ALDH2*1/*2(slow activity) or ALDH2*2/*2(almost non-functional)19. Here, ALDH2 is linked to familial pancreatic carcinoma.