Because the study by Kanda et al. has been the only study examining the combined effect of ADH1B and ALDH2 polymorphisms on the association between alcohol drinking and pancreatic cancer with a relatively small case sample size (n = 160), the current study aimed to investigate this topic with 419 pancreatic cancer cases and 963 controls recruited from a hospital in Taiwan, where the prevalence of ALDH2*2 carriers is the highest in the world (~ 50%). This evidence concerns the gene ADH1B and familial pancreatic carcinoma.