Notably, we also observed increased liver-weight-to-body-weight ratios, liver triglyceride contents, and serum ALT levels in Depdc5-LKO mice compared to LoxP mice, indicating Depdc5 deletion-mediated mTORC1 activation worsens the hepatic steatosis induced by ethanol (Fig. S3A–D). Here, DEPDC5 is linked to Hepatic steatosis.