In addition, hepatic mRNA levels of genes involved in lipid uptake (Fatp2, Fatp5) and very-low-density lipoprotein (VLDL) secretion (Mttp, Apob) were not significantly altered in pair- and ethanol-fed LoxP and Depdc5-LKO mice, indicating these two processes may not contribute to the development of alcohol-induced fatty liver in Depc5-LKO mice (Fig. 6A). This evidence concerns the gene DEPDC5 and fatty liver disease.